My first thought here was, "Is he going to tell me I'm stupid, or bust out a boom box and dance into my hospital room?" because with that expression which is so Gregory House, you just never know.
For all the negative space in the background, you've managed to make Hugh Laurie stand out brilliantly, so that the space actually compliments him instead of hindering the expanse of the drawing overall. This is a done and done and done character, but the way you've captured him is absolutely brilliant, and I'm glad to have been given the opportunity to see it.
The shading is top notch - the bleak dark by his nose and on his neck flows perfectly into the lighter areas, something that I could never really achieve without diligent hours of attempt (probably the main reason I stopped drawing as well). His stubble and his inquisitive eyebrow and frown make it so you know this is clearly not just Hugh Laurie; this is Dr.Gregory House you're dealing with.
My only complaint is his shoulder - it doesn't blend, cuts off into the white abruptly and looks as if it was an afterthought, or you just got a little lazy at the end (which is understandable!). This also applies to his ear, which is blown out and doesn't quite blend into the white background as nicely as it could.
But overall, with such an overdone subject, you've managed to impress me with a wonderful visual interpretation of one of my favorite fictional television characters. Thank you for making this so I could see it!

Many times people have drawn a portrait of Mr Hugh Laurie himself, usually as his character Dr Gregory House of the famous House MD series.

However, rarely people actually succeed in getting his likeness spot on and get that "House Character" on paper. I have to say you did a great job on getting his personality, which makes you recognize House (instead of Hugh Laurie) right away. Excellent work on that!

Great work on the shading, such as the blackness of the shading on (our) left, as well as the details you seem to have paid extra attention to. I'm especially amazed by the way your drawn the eye; it looks very realistic.

Keep up the amazing work and keep them coming! You're very talented. Don't let anyone else tell you otherwise!